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The principal cytochrome P450 isoenzyme concerned appears to generally be CYP2E1, with CYP1A2 and CYP3A4 as further pathways. Close to 85% of the oral dose appears from the urine within 24 several hours of administration, most as the glucuronide conjugate, with tiny amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity info.J